Principal component tests: applied to temporal gene expression data

BMC Bioinformatics

Table 1 Biologically functional enrichment analysis of the gene lists of eight clusters ^a

Cluster ID	Enriched PANTHER biological Processes	p-value ^b
CL1-1	lipid, fatty acid and steroid metabolism
	(GO: 0006629)	0.0003
	steroid metabolism (GO: 0008202)	0.0006
	cholesterol metabolism (GO: 0008203)	0.0253
CL1-2	blood clotting (GO: 0007596)	0.0068
	cell cycle (GO: 0007049)	0.0079
	oncogenesis	0.0101
	nucleoside, nucleotide and nucleic acid metabolism (GO: 0006139)	0.0119
	embryogenesis (GO: 0009700)	0.0435
	cell cycle control (GO: 0000074)	0.0376
	mRNA transcription (GO: 0006366)	0.0825
	cell proliferation and differentiation	0.0843
	(GO: 0031054; GO: 0008283) cell structure and motility (GO: 0007010)	0.0867
	immunity and defense (GO: 0006952)	0.0953
CL2-2	cell cycle	0.0325
CL2-7	No
CL2-13	No
CL2-14	immunity and defense (GO: 0006952)	0.0313
	developmental processes (GO: 0007275)	0.0432
	oncogenesis	0.0926
CL2-20	nucleoside, nucleotide and nucleic acid metabolism (GO: 0006139)	0.0796
CL2-23	lipid, fatty acid and steroid metabolism (GO: 0006629)	0.0084
	steroid metabolism (GO: 0008202)	0.0560

^a The aggregate of CL-1 and CL-2 approximately corresponds to the combination of CL2-2, CL-7, CL-13, CL-14, CL-20 and CL-23.
^b Corrected with Bonferroni method for multiple testing.

ISSN: 1471-2105