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Figure 3 | BMC Bioinformatics

Figure 3

From: Service-based analysis of biological pathways

Figure 3

Examples of Conceptual Process Model and Simple Pathway. Multiple examples of promotion, inhibition and indirect recognition can be found in these pathways. For example, (a) shows that 15 LO provides an operation called produce LXA4, which promotes the service of LXA4. (c) shows that upon injury, LTB4 recruits Neutrophil, promoting its service of producing COX2. (i) shows that Gastric Juice's service can inhibit the services of both Stomach Cell and Mucus. Examples of indirect recognition can be found in (h), where PLA2's service can liberate Arachidonic Acid, which can in turn be used as input to either the produce PGG2 operation of COX1's service or the produce PGE2 operation of the COX2 service. Examples of pre- and post-conditions can be found in (g), where NF-κ B/Rel when not phosphorylated can translocate from cytoplasm to cell nucleus, where it can stimulate proinflammatory gene transcription. NF-κ B/Rel's service, however, may be inhibited by the Iκ B service if NF-κ B/Rel is bound by its corresponding operation when Iκ B is not phosphorylated.

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