Figure 4

Flow chart demonstrating the functional annotation process. Functional annotation begins by accession mapping through ArrayIDer. ArrayIDer divides the input file into broad categories: predicted gene products, ESTs, non-NCBI predicted gene assemblies, and UniprotKB or Genbank RefSeq, as well as predicted proteins that were removed from the database. Predicted gene products go down the ISO pipeline, and the rest go through IEA pipelines, with the exception of UniprotKB or RefSeq, which are sent to GORetriever. GORetriever pulls out the genes which already have existing GO annotations, and the rest are manually curated by mapping orthologs to human, mouse, and rat genes.