Figure 1
From: Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100
MDM2 in surface representation, taken from various structures available in PDB, complexed with various ligands including WT p53 ( 1YCR), a β-hairpin peptide ( 2AXI), small molecule 'nutlin' ( 1RV1), an 8-mer p53 peptide analogue ( 2GV2), an optimized peptide ( 1T4F) and a 12 residue peptide. PDB codes have been mentioned at the right bottom of each structure. The location of Y100 on the surface has been mentioned for the WT structure. The surface was colored according to the charges of the surface residues: positive (blue), negative (red) and neutral (white).