Figure 6

Localization of the mutations extracted from the Pubmed abstracts within the structure of the Protein Kinase domain. The ATP binding pocket is represented with sticks. The DFG motif (activation segment, essential for kinase function) allocates a big number of mutations. The light brown Asparagine (central part of the figure) in the inter-lobe region, more than 10 mutations. The highest density residue is Lysine 64 (red), allocating 65 mutations. This residue has been reported as essential for protein function and ATP binding. We observe that most of the mutations allocate in or near the ATP binding pocket or the activation segment and that mutations outside the binding pocket correspond generally to low mutation density residues (colored in grey and green in the kinase domain model).