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Table 1 Mutations mapped to 1rw8A02. SwissProt accession P36897 maps directly to PDB code 1rw8 chain A and to CATH domain 1rw8A02 which represents residues 285–500. Other SwissProt entries containing known pathogenic deviations (PDs) are mapped to this domain via Gene3D and the mutations are mapped to the 1rw8 structure.

From: An integrated approach to the interpretation of Single Amino Acid Polymorphisms within the framework of CATH and Gene3D

SwissProt Accession

Domain Range

Sequence Identity

Mutations

P36897

285–500

100%

M318R, D400G, R487P

O00238

284–499

65%

R486W

P36894

314–529

62%

A338D, C376Y, M470T

P37023

282–497

60%

C344Y, R374W, M376R

   

I398N, W399S, R411P

   

R411Q, R411W, R484W

P37173

330–546

40%

Y336N, A355P, G357W

   

S449F, E526Q, R528C

   

R528H, R537C