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Figure 7 | BMC Bioinformatics

Figure 7

From: From SNPs to pathways: integration of functional effect of sequence variations on models of cell signalling pathways

Figure 7

Simplified schematic representation of the ErbB signalling model. ErbB receptor ligands (EGF and HRG) activate different ErbB receptor combinations, leading to recruitment of various adapter proteins (Grb2, Shc, and Gab1) and enzymes (PTP1-B, SOS, and RasGAP). These membrane recruitment steps eventually lead to the activation of ERK and Akt. The figure and legends are from the original publication [35].

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BMC Bioinformatics

ISSN: 1471-2105

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