Correlating protein function and stability through the analysis of single amino acid substitutions

BMC Bioinformatics

Table 1 Data set summary*.

	Total	FD	FSt	nFD	nFSt	Cut	FS (%F)	FnS	nFS (%S)	nFnS
PMD exp	64	36	16	9	3	-0.5/0.5	36 (69)	16	8 (19)	4
PMD all	3981	2841		1096		Man.	1932 (68)	909	744 (28)	396
PMD pbd	1657	849	326	322	160	-0.5/2.5	458 (39)	717	130 (22)	352
PMD foldx	810	401	205	126	78	-0.5/1.5	415 (69)	191	109 (21)	95
PMD 07	91	51		40		Man.	30 (59)	21	28 (48)	12

* The table summarizes counts of mutants in each data set broken up by effects on function and stability. In column names: (n)F – (n ot) f unctionally disruptive, (%F) indicates the percentage of all functionally disruptive mutations in the set, D – d estabilizing, St – st abilizing, (n)S – (n ot) s tructurally disruptive, (%S) indicates the percentage of all structurally disruptive mutations. Cut is the cutoff in kcal/mol used to determine structural disruption (stabilizing/destabilizing cutoffs;Man. means the annotation for the set was manually performed and not described in numbers).

ISSN: 1471-2105