(a) Degrees and (b) mRNA expression changes of AML genes. Each figure shows node degrees and magnitudes of differential expression (DES) for AML-causing mutation genes found in subnetworks (AML_Network), all known AML mutation genes (AML), and all genes in the whole network. The bottom and top of each box are first and third quartiles, and the band near the middle of the box is the median. Whiskers extend to at most 1.5 times the inter-quartile range. Beyond the whiskers, all outliers are shown in open circles. The statistical significances for differences between two groups of genes (e.g. AML_Network vs. All genes) measured by non-parametric Wilcoxon rank-sum test are denoted below the labels of gene groups.