Details on the expression biomodule associated with BCR-ABL and T-ALL phenotypes and the epigenetic mechanism of HDAC4. The ESG (gene symbol in red) is positively correlated with part of its GEMs (n = 10) as down-regulated in "BCR-ABL" and up-regulated in "T-ALL", and negatively correlated with another parts of its GEMs (n = 36). 47 genes were derived from PGnet under optimal threshold (Suppl. Table 3 (Additional file 4)). The standard full agglomerative hierarchical clustering was performed on Spearman's rank correlation distance of normalized expression levels. The resulting heatmap was drawn using Bioconductor package made4.