Figure 9

A real example of non-BBH true one-to-one ortholog pairs in the human-mouse comparison caught by MSOAR 2.0 in the post-processing step. Four one-to-one ortholog pairs were assigned by MSOAR between two corresponding orthologous blocks on human chromosome 10 (7,244,255 bp-7,900,507 bp) and mouse chromosome 2 (9,977,663 bp-10,636,794 bp). The genes ITIH2 and Itih2 were not assigned orthology by MSOAR, since ITIH2 is not among the top hits of Itih2. However, because Itih2 is the best hit of ITIH2 and the genes are located in corresponding "gaps", MSOAR 2.0 outputs them as an additional one-to-one ortholog pair.