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Table 1 Genes with significant mutation clusters (Probability < 0.01)

From: Statistical method on nonrandom clustering with application to somatic mutations in cancer

Gene Cluster
size
Cluster
positions
Number of
mutations in
cluster
Cumulative cluster
probability*
KRAS (188 aa) 2 12-13 131 1.47E-234
BRAF (766 aa) 1 600-600 60 2.02E-157
TP53 (393 aa) 155 132-286 326 3.07E-101
NRAS (189 aa) 1 61-61 33 7.11E-62
PIK3CA (1068 aa) 5 542-546 27 7.09E-46
CTNNB1 (781 aa) 13 33-45 12 8.54E-19
ERBB2 (1255 aa) 1 776-776 2 7.97e-4
HRAS (189 aa) 1 61-61 4 2.06E-06
PTEN (403 aa) 63 111-173 8 5.50E-05
MAP2K7 (419 aa) 1 162-162 2 0.002386
LRRK2 (2534 aa) 4 1723-1726 2 0.003547
  1. *: only most significant cluster per gene is listed