Indirect two-sided relative ranking: a robust similarity measure for gene expression data

BMC Bioinformatics

Table 5 Statistical Analysis of the Improvement in Rank

Therapeutic Use	N	Mean Improvement	StdDev	tValue	P
analgesic	29	90.43	117.55	4.14	0.0003
anti-inflammatory	160	30.12	115.04	3.31	0.0011
anti-psychotic (neurole)	69	25.57	73.36	2.90	0.0051
immunosuppressive agent	67	7.96	40.42	1.61	0.1120
tranquilizer	68	14.43	73.95	1.61	0.1124
cardiovascular agent	22	10.82	69.37	0.73	0.4726
anti-neoplastic	54	10.33	114.65	0.66	0.5106
anti-convulsant	144	-4.50	92.09	-0.59	0.5585
anti-proliferative	86	-1.86	77.86	-0.22	0.8252

A paired t-test was performed to analyze the difference in the rank of true positives returned by the direct and indirect method. N is the number of true positives found within the top 100 results across the whole therapeutic group. Improvement is the average improvement (rank direct - rank indirect).

ISSN: 1471-2105