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Table 6 Performance comparison with different methods based on the independent test set

From: APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility

Method

Specificity

Recall

Precision

F1

ΔF1

Robetta

0.87

0.33

0.52

0.40

**

FOLDEF

0.88

0.26

0.48

0.34

-0.06

KFC

0.85

0.31

0.48

0.37

-0.03

MINERVA

0.90

0.44

0.65

0.52

+0.12

APIS (this work)

0.76

0.72

0.57

0.64

+0.24

  1. The highest value in each column is shown in bold.