Figure 1

GISTIC applied to example. Represented is a toy chromosome for 5 samples. The X axis corresponds to consecutive markers across the chromosome and each bar represents the G-score contribution of that marker. Two possible cut-offs determined by focal GISTIC are represented by dotted blue and red lines, these cut-offs are determined based on broad regions in other chromosomes (which are not shown in the Figure for the sake of clarity). Three results from GISTIC are contemplated: standard (A), focal based on the blue threshold (B) and focal based on the red threshold (C). Reported peaks are displayed as green bars at the top, Focal GISTIC's ability to capture additional peaks is dependent on the threshold determined by aberrations in other chromosomes.