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Table 1 Mean amino sequence features and p-values for all bacterial targets, E. coli targets and non-targets.

From: Properties and identification of antibiotic drug targets

Feature

Non-targets

Bacterial targets

p-value comparing all targets to non-targets

E. coli targets

p-value comparing E. coli targets to non-targets

Length

316

420

0.032

515

0.001

% Trp

1.52

0.98

0.005

0.74

6 × 10-5

% Met

2.95

2.54

0.099

2.26

0.015

% Val

7.11

7.85

0.0002

7.94

0.017

% Pro

4.67

5.52

0.007

5.45

0.042

% Leu

10.63

8.91

4 × 10-6

9.36

0.046

% Gln

3.92

3.43

0.049

3.19

0.078

% Gly

7.1

7.70

0.099

7.75

0.12

% Glu

5.83

6.46

0.32

6.41

0.22

% Lys

4.31

4.33

0.40

4.54

0.29

% Arg

5.58

5.31

0.58

6.51

0.33

% Asp

5.05

5.89

0.008

5.39

0.38

% Thr

5.35

5.80

0.074

5.58

0.38

% Cys

1.3

0.96

0.01

1.07

0.39

% Tyr

2.79

2.97

0.87

2.83

0.6

% His

2.31

2.12

0.78

2.23

0.62

% Phe

6.12

5.79

0.24

5.75

0.66

% Ala

5.82

5.87

0.92

5.6

0.69

% Asn

3.87

3.98

0.99

3.65

0.93

% Ser

9.37

9.39

0.49

9.29

0.96

% Ile

4.4

4.18

0.54

4.46

0.99

Hydrophobicity

-21

-85

0.049

-93

0.067

SignalP

0.2

*

*

0.2

0.83

NetNGlyc

1.1

1.3

0.52

1.1

0.75

NetOGlyc-S

0.1

0.00

0.57

0

0.29

NetOGlyc-T

0.6

0.7

0.15

0.5

0.97

LCR

0.9

0.9

0.80

0.9

0.84

% α-Helix

42

32

3 × 10-4

32

0.015

% β-Sheet

15

21

1.5 × 10-4

22

0.002

THMM

1.4

0.3

0.023

0.5

0.009

pI

7.1

7.0

0.67

6.9

0.4

  1. * Not applied as the prediction program as bacterial targets are both gram positive and gram negative.