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Figure 2 | BMC Bioinformatics

Figure 2

From: BISMA - Fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences

Figure 2

Improved algorithm for CpG methylation state determination as implemented in the BISMA software. BISMA detects CpG sites in the reference sequence which is aligned to the experimental sequences. After identification of a guanine at the position aligned to the reference CpG's guanine, the next base in 5' direction is used for determination of the methylation state. Methylation state "unknown" refers to sites lacking clear methylation information due to mutations or sequencing problems.

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BMC Bioinformatics

ISSN: 1471-2105

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