Figure 5

Comparison of estimated firing efficiencies of origins in S.cerevisiae. (A) Estimated firing efficiencies of origins on Chromosome VI of S.cerevisiae. The height of the vertical bar shows our estimation by applying the proposed SFTM to two microarray timecourse data sets (Cer-Raghuraman and Cer-Alvino) and Friedman's estimation by using 2-D gel electrophoresis [7]. The error bar of 2-D gel estimation reflects the variation in firing efficiencies among different strains. (B) Pairwise scatter plots of origin firing efficiencies estimated from three sources in (A). The correlation coefficients are shown at the top of the respective figures. The good consistency between these results suggests that SFTM is a valid method to estimate firing efficiency. (C) Scatter plot of the estimated firing efficiencies of the matched origins from two S.cerevisiae data sets Cer-Raghuraman and Cer-Alvino by applying SFTM.