Figure 6

Comparison of estimated firing efficiencies of origins in S.pombe. (A) Comparison of estimated S.pombe origin efficiencies from single DNA molecular technique (Patel et al, 2006) and the proposed SFTM model applied to the Pom-Heichinger microarray data. The efficiencies of 11 origins estimated by both methods are plotted against each other. (B) Comparison of estimated origin efficiencies by measuring the signal ratio in the HU experiment (Heichinger et al, 2006) and the proposed SFTM model applied to the Pom-Heichinger time-course microarray data. (C) Comparison of estimated origin efficiencies by applying the proposed SFTM model to two microarray datasets: Pom-Heichinger and Pom-Eshaghi. (D) Comparison of estimated origin efficiencies by applying the proposed SFTM model to the two repeats of DNA replication dataset Pom-Eshaghi. The red line in these figures shows a linear fitting (without intercept) of the two estimations illustrated in each figure. The good consistency between these results indicates that SFTM is a reliable and valid method to estimate firing efficiency at genomic scale.