Figure 4

The process of building the enumeration tree for target information in Table 3. The rhombus represents the root of the tree. The circles represent the genes inserted into the tree. The squares represent the leaves, which store two sets of miRNAs - human and viral. These miRNAs are common "targeters" to all the genes in the path from the leaf to the root. Viral miRNAs are labeled with uppercase letters and the human miRNAs are labeled with numbers. The rectangles indicate modules that are pruned from the tree for one of two reasons: (1) modules that break the quorum are in solid rectangles (in this example the required quorum is 1 viral miRNA and 2 human miRNAs); (2) redundant modules (which are fully contained in another module) are in dotted rectangles. The arrow indicates the containment, starting from the redundant module and ending in the bigger one. The three sub-figures (a), (b), and (c) show the insertion of genes b and c, d, and a into the tree, respectively.