Figure 4

The box plot of average rmsd within and between clusters of MMP-1 (A), MMP-13D (B), and MMP-13P (C). From each cluster, the medoid conformer was selected and the structural rmsd between the medoid and the rest of the group members was calculated (median at (A) 2.05 Å, (B) 1.45 Å, (C) 1.63 Å). Similarly the rmsd between each medoid and the members of the other groups was also calculated (median at (A) 2.65 Å, (B) 1.87 Å, (C) 2.78 Å).