Figure 5

The pocket shapes of the known ligand-bound crystal structures in MMP-1. The pocket shapes of the four known conformers were compared visually by depicting the pocket points with the following coloring scheme: the 578 points always free of contacts were in green, while the 231 conditional points were either in red (free of contacts) or in blue (in contacts). Only in 966c was the pocket deep (shown in red) enough to accommodate rs2. In the other three structures, the pocket residues occupied this region (shown in blue).