Figure 5

Graphical output of a detected and validated mVIS in the MeDIP-study. Panel A illustrates the detected mVIS which are subject to DNA methylation. Only a section of the detected region-of-interest has an increased probe-intensity; the probe-significance signifying this subregion. Directly beside the increased probe-significance, a restriction cleavage site is indicated by means of a green bar. Due to the palindrome sequence, these sites are indicated at the same genomic position on both DNA strands. Panel B shows the detected statistically significant regions among the different thresholds, and window sizes with various colors. A schematic representation of the amplified genomic region, with the virus- and the murine contribution, is shown in Panel C.