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Table 1 Motif enrichment analysis.

From: HAT: Hypergeometric Analysis of Tiling-arrays with application to promoter-GeneChip data

 

MAT

HAT

Nr

Motif

Hits

Fold- change

p -value

Motif

Hits

Fold- change

p -value

1

AP2alpha

9735

1.606

0.0

M00117.CEBPbeta

1532

2.325

2.837E-185

2

Elk-1

5380

1.707

9.226E-286

M00770.CEBP

3076

1.766

2.229E-183

3

M00470.AP-2 gamma

5938

1.641

1.823E-274

M00912.C-EBP

3036

1.715

1.309E-164

4

M00109.CEBPbeta

6170

1.617

3.519E-269

cEBP

1928

1.965

1.886E-157

5

M00695.ETF

3449

1.885

3.049E-250

M00116.CEBPalpha

2689

1.722

4.296E-148

6

M00025.Elk-1

2979

1.949

1.763E-237

M00109.CEBPbeta

1278

2.161

2.349E-132

7

M00446.Spz1

4863

1.665

3.901E-237

M00190.CEBP

2402

1.719

9.670E-132

8

M00008.Sp1

5135

1.625

1.038E-228

M00098.Pax-2

1799

1.578

8.565E-73

9

E74A

3635

1.691

7.076E-188

M00496.STAT1

1909

1.545

8.877E-71

10

M00771.ETS

3756

1.674

2.374E-187

M00971.Ets

1917

1.508

4.418E-64

  1. The top 10 motifs enriched in the detected regions-of-interest (α = 1 × 10-5) by HAT and MAT for the cebpa-study (ChIP-on-chip). Among the top 10 motifs enriched in the regions-of-interest detected with HAT, seven contained the CEBP binding motif whereas for MAT, only one contained the CEBP binding motif. For each reported motif, the number of hits within the regions-of-interest are counted, their fold change computed, and the p-value derived using the binomial test.
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BMC Bioinformatics

ISSN: 1471-2105

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