Figure 5

Ranking of the interface relative to all possible surface patches. Distribution of the degree of clustering of conserved residues within interfaces as compared to other surface patches for (A) homodimers, and (B) protein complexes. For each protein, the interface is ranked, relative to all other surface patches, as being in the top 10% (rank 1), 10-20% (rank 2), etc. according to the ρ value (Eq. 4). Methods 1-3 for generating the surface patches are described in Methods. (C) For each protein, the generated surface patch having the maximum overlap with the true interface is found out and the distribution of the % overlap is plotted for all proteins belonging to the two datasets.