Figure 6

Comparison of the clustering of conserved residues within the interface and other surface patches of human carboxypeptidase complexed to its inhibitor (PDB file, 1dtd). (A) The chain of interest (carboxypeptidase) is shown in spacefill (grey), its partner (inhibitor) in cartoon representation (yellow) in two different orientations. Conserved interface residues (on the enzyme) are colored green, the remaining interface residues are in blue. The partner protein is removed in the third view to clearly show the clustered nature of the conserved residues within the interface. (B) Diagram showing the construction of surface patches around each surface residue using a fixed cutoff of 15 Å (Method 1). (C) Sixteen different surface patches of the protein (in grey) are shown, in each of them the conserved residues (green) are scattered over the entire patch.