Cultures can be spotted or pinned onto agar. A) 16 different S. cerevisiae mutant cultures growing in 384-format on solid agar after inoculation by spotting of dilute liquid inoculum. B) The same 16 mutants, growing in quadruplicate cultures on a different plate in the same location, in 1536-format , inoculated by direct pinning onto agar. Images were simultaneously captured 2 days after inoculation. Mutant specific differences in cell densities are apparent in both images, but more pronounced in panel A.