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Table 3 A ranked list of all features used in this work. The score is calculated by the ReliefF method

From: TargetSpy: a supervised machine learning approach for microRNA target prediction

Rank Features Score
1 Number of base parings to the microRNA 8-mer seed 0.03175
2 G+C content of target site 0.01263
3 Number of base pairings to the first 8 nucleotides of the microRNA 3' end 0.01038
4 Number of consecutive base-pairings to the microRNA 3' end with two allowed non-pairing positions 0.00995
5 Occurrence of CpG in target site 0.00799
6 G+C content ratio between the microRNA and the target site 0.00642
7 Compactness 0.00619
8 T9 anchor 0.00556
9 Longest stretch of consecutive base-pairings in the hybrid 0.00513
10 Number of bulges in the microRNA of size three 0.00498
11 T1 S/W anchor 0.00491
12 Total number of base-pairings 0.00475
13 Number of bulges on the target site of size seven or greater 0.00442
14 T1 anchor 0.00434
15 Number of bulges in the microRNA of size two 0.00433
16 Occurrence of CpG in the upstream flanking area 0.00383
17 Number of bulges in the target site of size one 0.00374
18 Total bulge length of the target site 0.00362
19 Length of the target site 0.00336
20 Total bulge length of the microRNA 0.00334
21 Target site position within the 3'UTR 0.00333
22 Number of symmetric bulges 0.00290
23 G + C content upstream of the target site 0.00287
24 Number of bulges on the target site 0.00286
25 Length of the second largest bulge on the target site 0.00268
26 Mean length of bulges on the target site 0.00263
27 T9 S/W anchor 0.00261
28 Binding asymmetry 0.00255
29 Number of bulges in the target site of size two 0.00240
30 Total number of G:U wobble base pairs 0.00227
31 Local RISC accessibility 30/30 0.00220
32 Local RISC accessibility 3/15 0.00215
33 Number of bulges in the target site of size four 0.00210
34 Difference in G+C content between the first and the last nt of the target site 0.00201
35 Occurrence of CpG in downstream flanking area 0.00179
36 Number of bulges in the microRNA of size one 0.00179
37 Length of the second largest bulge on the microRNA 0.00174
38 Number of bulges on the microRNA 0.00153
39 Number of bulges in the microRNA of size five 0.00128
40 Number of bulges in the target site of size three 0.00113
41 Difference in G + C content between the target site and the 20 nt upstream and downstream flanking region 0.00112
42 Number of bulges in the target site of size five 0.00100
43 Number of bulges in the microRNA of size four 0.00084
44 G+C content downstream of the target site 0.00084
45 Number of bulges in the target site of size six 0.00021