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Table 3 IAP values obtained by 20-fold multiple splitting

From: Functional classification of proteins based on projection of amino acid sequences: application for prediction of protein kinase substrates

Kinase type

All species

Human

 

No

LOO CV

M

SD

No

LOO CV

M

SD

ABL1

32

0.661

0.685

0.072

24

0.600

0.600

0.106

ATM

30

0.779

0.751

0.086

29

0.771

0.762

0.075

AURORA_A

12

0.792

0.777

0.130

-

   

AURORA_B

14

0.858

0.857

0.114

11

0.808

0.815

0.115

CAM_II_group

40

0.707

0.657

0.084

19

0.651

0.681

0.090

CAM_KII_alpha

21

0.531

0.515

0.120

16

0.475

0.494

0.111

CDK1

69

0.648

0.641

0.049

62

0.679

0.653

0.064

CDK2

28

0.761

0.740

0.066

21

0.659

0.666

0.092

CDKgroup

47

0.682

0.653

0.065

30

0.546

0.534

0.080

CK1alpha

11

0.609

0.595

0.134

10

0.548

0.535

0.097

CK1group

18

0.637

0.622

0.158

10

0.487

0.508

0.182

CK2group

122

0.746

0.734

0.041

87

0.680

0.670

0.046

DNA_PK

11

0.508

0.466

0.121

-

   

EGFR

27

0.861

0.808

0.090

21

0.723

0.728

0.092

ERK1

71

0.697

0.624

0.048

54

0.621

0.637

0.054

ERK2

61

0.632

0.673

0.038

52

0.662

0.656

0.048

FYN

25

0.696

0.726

0.083

19

0.625

0.664

0.096

GSK3beta

26

0.688

0.671

0.087

20

0.606

0.588

0.125

GSKgroup

20

0.616

0.599

0.113

13

0.648

0.620

0.183

INS_R

13

0.685

0.583

0.133

-

   

JNK1

20

0.766

0.763

0.093

15

0.786

0.759

0.121

JNK2

10

0.653

0.634

0.125

-

   

LCK

29

0.824

0.795

0.058

24

0.787

0.792

0.072

LKB1

16

0.994

0.993

0.003

15

0.995

0.995

0.005

LYN

26

0.722

0.745

0.090

20

0.699

0.691

0.118

MAPKAPK2

17

0.641

0.652

0.082

15

0.590

0.596

0.081

MAPKgroup

36

0.676

0.661

0.063

31

0.625

0.614

0.089

PAK1

21

0.573

0.574

0.098

16

0.527

0.514

0.092

PDK-1

24

0.957

0.956

0.038

19

0.942

0.933

0.079

PKAalpha

22

0.409

0.466

0.108

-

   

PKAgroup

206

0.668

0.655

0.028

138

0.595

0.593

0.037

PKBgroup

63

0.655

0.650

0.051

55

0.625

0.624

0.038

PKCalpha

81

0.643

0.627

0.054

68

0.648

0.630

0.053

PKCbeta

10

0.364

0.383

0.155

-

   

PKCdelta

17

0.49

0.507

0.111

16

0.382

0.439

0.115

PKCgroup

145

0.757

0.755

0.036

84

0.691

0.656

0.046

PKCzeta

11

0.701

0.670

0.207

10

0.646

0.584

0.170

PKGgroup

10

0.551

0.642

0.187

-

   

PLK1

18

0.718

0.661

0.163

17

0.699

0.669

0.119

ROCKgroup

12

0.856

0.839

0.155

-

   

RSKgroup

18

0.658

0.644

0.095

14

0.471

0.511

0.146

SGKgroup

11

0.695

0.685

0.182

10

0.600

0.543

0.159

SRC

92

0.742

0.717

0.043

65

0.656

0.627

0.052

SYK

21

0.766

0.709

0.158

17

0.689

0.615

0.179

p38alpha

24

0.737

0.700

0.083

23

0.767

0.786

0.065

Average

 

0.689

0.677

0.096

 

0.654

0.648

0.094

  1. The calculation was performed for the whole training set (1021 substrate proteins) and subset, including only human proteins (709). The numbers of the substrates in each class (No) are presented. IAP values were calculated by LOO CV procedure. The IAP values, averaged on 20 rounds of multiple splitting (M) and their standard deviations (SD), are presented. The kinase substrate classes containing less than 10 proteins (for human) are excluded.
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BMC Bioinformatics

ISSN: 1471-2105

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