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Table 3 IAP values obtained by 20-fold multiple splitting

From: Functional classification of proteins based on projection of amino acid sequences: application for prediction of protein kinase substrates

Kinase type All species Human
  No LOO CV M SD No LOO CV M SD
ABL1 32 0.661 0.685 0.072 24 0.600 0.600 0.106
ATM 30 0.779 0.751 0.086 29 0.771 0.762 0.075
AURORA_A 12 0.792 0.777 0.130 -    
AURORA_B 14 0.858 0.857 0.114 11 0.808 0.815 0.115
CAM_II_group 40 0.707 0.657 0.084 19 0.651 0.681 0.090
CAM_KII_alpha 21 0.531 0.515 0.120 16 0.475 0.494 0.111
CDK1 69 0.648 0.641 0.049 62 0.679 0.653 0.064
CDK2 28 0.761 0.740 0.066 21 0.659 0.666 0.092
CDKgroup 47 0.682 0.653 0.065 30 0.546 0.534 0.080
CK1alpha 11 0.609 0.595 0.134 10 0.548 0.535 0.097
CK1group 18 0.637 0.622 0.158 10 0.487 0.508 0.182
CK2group 122 0.746 0.734 0.041 87 0.680 0.670 0.046
DNA_PK 11 0.508 0.466 0.121 -    
EGFR 27 0.861 0.808 0.090 21 0.723 0.728 0.092
ERK1 71 0.697 0.624 0.048 54 0.621 0.637 0.054
ERK2 61 0.632 0.673 0.038 52 0.662 0.656 0.048
FYN 25 0.696 0.726 0.083 19 0.625 0.664 0.096
GSK3beta 26 0.688 0.671 0.087 20 0.606 0.588 0.125
GSKgroup 20 0.616 0.599 0.113 13 0.648 0.620 0.183
INS_R 13 0.685 0.583 0.133 -    
JNK1 20 0.766 0.763 0.093 15 0.786 0.759 0.121
JNK2 10 0.653 0.634 0.125 -    
LCK 29 0.824 0.795 0.058 24 0.787 0.792 0.072
LKB1 16 0.994 0.993 0.003 15 0.995 0.995 0.005
LYN 26 0.722 0.745 0.090 20 0.699 0.691 0.118
MAPKAPK2 17 0.641 0.652 0.082 15 0.590 0.596 0.081
MAPKgroup 36 0.676 0.661 0.063 31 0.625 0.614 0.089
PAK1 21 0.573 0.574 0.098 16 0.527 0.514 0.092
PDK-1 24 0.957 0.956 0.038 19 0.942 0.933 0.079
PKAalpha 22 0.409 0.466 0.108 -    
PKAgroup 206 0.668 0.655 0.028 138 0.595 0.593 0.037
PKBgroup 63 0.655 0.650 0.051 55 0.625 0.624 0.038
PKCalpha 81 0.643 0.627 0.054 68 0.648 0.630 0.053
PKCbeta 10 0.364 0.383 0.155 -    
PKCdelta 17 0.49 0.507 0.111 16 0.382 0.439 0.115
PKCgroup 145 0.757 0.755 0.036 84 0.691 0.656 0.046
PKCzeta 11 0.701 0.670 0.207 10 0.646 0.584 0.170
PKGgroup 10 0.551 0.642 0.187 -    
PLK1 18 0.718 0.661 0.163 17 0.699 0.669 0.119
ROCKgroup 12 0.856 0.839 0.155 -    
RSKgroup 18 0.658 0.644 0.095 14 0.471 0.511 0.146
SGKgroup 11 0.695 0.685 0.182 10 0.600 0.543 0.159
SRC 92 0.742 0.717 0.043 65 0.656 0.627 0.052
SYK 21 0.766 0.709 0.158 17 0.689 0.615 0.179
p38alpha 24 0.737 0.700 0.083 23 0.767 0.786 0.065
Average   0.689 0.677 0.096   0.654 0.648 0.094
  1. The calculation was performed for the whole training set (1021 substrate proteins) and subset, including only human proteins (709). The numbers of the substrates in each class (No) are presented. IAP values were calculated by LOO CV procedure. The IAP values, averaged on 20 rounds of multiple splitting (M) and their standard deviations (SD), are presented. The kinase substrate classes containing less than 10 proteins (for human) are excluded.