Figure 1
From: CONAN: copy number variation analysis software for genome-wide association studies

Software Architecture. (A) In traditional approaches the application requests data, processes it locally and uploads the results. Thus, additional amount of data transfer reduce the performance. (B) The two-tier architecture of CONAN outsources all data intensive algorithms on the database server. The client invokes stored procedures to execute them on the database server itself; thus no upload of data is required and the client retrieves only the informative results.