Figure 3

Caspase cleavage products identified based on MS/MS-data. Protein identifications were done with Mascot against a database of predicted caspase cleavage products created with Pripper (Vote-classifier: SVM-6-4 and RF-12-12). Complete protein sequences are shown with all the identified peptides (red), caspase cleavage motifs (yellow) and peptides identified at the cleavage site (black box). Peptide spectrum matches for the cleavage site peptides are also shown. A) Cytokeratin 18 identified from the 2-DE sample B) Potential new caspase target leukosialin identified from the iTRAQ-sample.