Figure 1

An overview of protein complex prediction that considers the physical binding domain. The key idea of our approach is shown in Figure 1. A densely connected protein cluster in the protein-level interaction (i) is not always the protein complex in which the member proteins can bind to each other at the same time when we consider the domain-level interactions (ii and iii); In case (ii), each protein has a sufficient number of domains to bind to each other whereas in case (iii), there are too few domains for each protein and the proteins cannot simultaneously bind to each other. Figure 2 is an overview of our method with its two main steps, extraction of protein clusters and verification of the protein clusters based on the physical binding domains.