Figure 6
From: rSW-seq: Algorithm for detection of copy number alterations in deep sequencing data
Simulation tests for complex alterations and performance of rSW-seq. (A) The performance in identification of focal, two copy number changes (4 copies) of various sizes (50 kb--300 kb) from 1 Mb single copy gains. The sensitivity (S) and precision (P) are shown for four size categories at different t levels. (B) The homozygous deletions (zero copy) nested in single copy losses were similarly tested. (C) Five alterations with different copy numbers (0 ~ 4 copies) are positioned in a complex configuration. The alterations are indexed (#1 - #5) in chromosomal order. The focal high-level amplification (#2) and homozygous deletion (#5) are nested within the larger single copy gain (#1) and loss (#4) (D) The observed alterations identified by rSW-seq were classified according to their expected copy numbers and compared with the 5 predefined alterations.