Efficient Bayesian approach for multilocus association mapping including gene-gene interactions

BMC Bioinformatics

Table 1 SNP posterior odds summaries

Type	GRR	MAF	Max Score	Accuracy
Multiplicative	1.3	0.05	[-6.1,1.6]	0.57
	1.3	0.1	[-4.6,7.0]	0.89
	1.3	0.2	[-2.0,11.3]	0.96
	1.6	0.05	[-6.0,6.8]	0.88
	1.6	0.1	[-0.5,44.9]	0.96
	1.6	0.2	[0.6,71.9]	1.00
	2.0	0.05	[-0.6,23.9]	0.95
	2.0	0.1	[1.2,77.6]	1.00
	2.0	0.2	[3.8,129.4]	0.99
Threshold	1.3	0.05	[-6.8,-1.0]	0.38
	1.3	0.1	[-6.4,-0.6]	0.34
	1.3	0.2	[-6.2,0.2]	0.55
	1.6	0.05	[-7.0,-1.3]	0.34
	1.6	0.1	[-7.4,0.3]	0.38
	1.6	0.2	[-3.4,16.3]	0.96
	2.0	0.05	[-6.3,-0.6]	0.40
	2.0	0.1	[-6.1,8.1]	0.80
	2.0	0.2	[-0.7,43.5]	1.00
Triplet	1.3	0.05	[-6.2,-1.3]	0.28
	1.3	0.1	[-6.3,1.1]	0.41
	1.3	0.2	[-7.7,0.5]	0.47
	1.6	0.05	[-6.9,0.6]	0.41
	1.6	0.1	[-9.9,0.6]	0.59
	1.6	0.2	[-5.4,4.6]	0.85
	2.0	0.05	[-7.2,1.6]	0.43
	2.0	0.1	[-5.5,11.7]	0.80
	2.0	0.2	[-2.7,22.8]	0.95

The table shows summary information about the maximum BMA scores, i.e. log posterior odds values, obtained for SNPs residing in the causal areas in the simulated data sets. The Max Score column reports the empirical 95% interval for the highest score observed for a SNP within any causal area in a data set. The Accuracy column reports the proportion of all data sets in which the SNP assigned the highest score among all SNPs in a data set belonged to a causal area. The values reported on each row are based on 100 simulated data sets.

ISSN: 1471-2105