Comparison of the performance of three TRNI algorithms. Plots of precision vs. sensitivity for three TRNI methods applied to the E. coli compendium: correlation, CLR, and partial correlation. The partial correlation result used the set of 179 known TFs in RegulonDB as regressors. This was the best result observed for partial correlation in Additional file 1, Supplementary Figure S1A. AUC10 is the area under the precision vs. sensitivity curve but above 10% precision. The dashed black line indicates 10% precision.