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Table 1 Fisher's exact test for statistically overrepresented pathways among CCA results.

From: Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of metabolic syndrome

Pathway

Odds Ratio

Expected Count

Actual Count

Pathway Size

p value

Selenoamino acid metabolism

3.240

3.694

8

17

0.018

Neuroactive ligand-receptor interaction

2.265

7.388

13

34

0.020

Histidine metabolism

2.915

3.911

8

18

0.026

Arginine and proline metabolism

2.363

6.084

11

28

0.026

Fc epsilon RI signaling pathway

2.192

6.953

12

32

0.030

Pancreatic cancer

1.961

9.343

15

43

0.032

Glycerolipid metabolism

2.523

4.780

9

22

0.033

Steroid biosynthesis

3.630

2.173

5

10

0.045

Heparan sulfate biosynthesis

3.630

2.173

5

10

0.045

  1. Expected count represents the expected number of MetS associated genes in each pathway based on the overall number of MetS associated genes in the dataset, total number of genes tested, and size of the pathway.
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BMC Bioinformatics

ISSN: 1471-2105

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