Example of HOPE's output. A simplified example of HOPE's output. A) Explanation of the used method (structure, modelling or predictions) and links to the relevant databases. B) Text and pictures that explain the differences between the wild-type and mutant residue. (Text is left out of this figure for clarity.) C) Paragraph of the report explaining the effect of the mutation on contacts made by the residue, a disulfid bond in this case. It contains a link to the wiki-entry "cysteine" and "disulfid bond". D) Images/animations that show the effect of the mutation on the structure.