Genome scale prediction of substrate specificity for acyl adenylate superfamily of enzymes based on active site residue profiles

Table 5 Identification and annotation of new members of the acyl-adenylate superfamily.

Subfamily	AMP-ligases (1499)	Hypothetical proteins (235)	Unnamed proteins (64)	Putative proteins (473)	Unknown proteins (5)
AcCS	266	42	21	54	0
4CL	12	7	0	11	1
MCS	151	16	4	23	0
LCS	1065	162	39	341	4
Luciferase	0	0	0	0	0
NRPS	5	8	0	44	0
Total	2276

The numbers within parenthesis in the top row indicate total number of proteins in NR database which have been originally annotated as acyl-AMP ligases, putative proteins or unknown proteins due to lack of suitable tools for assigning substrate preference. The various rows indicate the number of such proteins which could be grouped into various subfamilies by our substrate specificity prediction methods.

ISSN: 1471-2105