Two workflows involved in the calibration (A) and simulation (B) of parameterised SBML models using COPASIWS. (A) The calibration workflow is asynchronous due to the compute-intensive nature of the process. It makes a series of calls to the COPASI web service from the submission and initiation of the calibration task, ending with the retrieval of the results. (B) The simulation workflow is synchronous, making a single call to COPASIWS to parameterise it with input data and waits for the generation of the SBRML file containing the results of the simulation. These results are also plotted as a graph by the workflow (C).