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Table 4 Summary of leaves providing maximum separation between amyloidogenic and non-amyloidogenic derivatives of different germline sets*

From: Using simple artificial intelligence methods for predicting amyloidogenesis in antibodies

Leaf J00248 M30446 X72813 X93620 X93627 X93632 X93640 Z22188 Z22191 Z22197 Z22208 Z73673
1 0.091 0.009 0.024 -0.016 0.042 0.046 -0.001 0.044 0.028 0.036 -0.032 -0.036
2 -0.030 0.008 0.009 -0.013 -0.135 -0.093 0.022 -0.075 0.073 0.089 0.052 0.062
3 -0.038 -0.001 0.071 -0.035 -0.038 -0.209 0.100 -0.085 -0.035 -0.017 0.068 0.003
4 -0.058 0.030 -0.145 -0.017 0.053 0.116 -0.008 -0.123 0.058 -0.198 0.039 0.014
5 -0.044 0.007 0.056 0.065 0.018 0.070 -0.009 -0.081 -0.092 -0.057 -0.025 0.008
6 0.132 -0.028 0.043 0.004 0.026 0.070 0.012 0.079 0.058 0.026 -0.006 -0.029
7 -0.058 -0.031 -0.054 -0.052 -0.048 0.000 -0.018 0.102 -0.082 0.158 -0.105 -0.016
8 0.007 0.006 0.066 0.063 0.083 0.00 -0.099 0.139 -0.011 -0.037 0.009 0.040
  1. * Values were obtained by substracting the percentage of mutations in non-amyloidogenic derivatives from the percentage of mutations in amyloidogenic derivatives terminating in a given leaf. Minimum and maximum values per germline set, which were used to identify the paths where scores were decreased and boosted, respectively, are shown in italics and boldface, respectively.