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Table 1 Reactions involved in the MEV pathway (in order of occurrence)

From: Simulation of a Petri net-based Model of the Terpenoid Biosynthesis Pathway

Ordera

Reaction

Enzyme

Main productb

1

acetylcoA + acetylcoA → acetoacetyl-coA + coA

acetylcoA C-acyltransferase

(EC 2.3.1.9)

acetoacetyl-coA

2

acetoacetylcoA + acetylcoA + H2O → HMGcoA + coA

HMGcoA synthase (EC2.3.3.10)

HMGcoA

3

HMGcoA + 2NADPH + 2H+ → mevalonate + coA + 2 NADP+

HMGcoA reductase (EC 1.1.1.34)

MEV

4

MEV + ATP → MEVP + ADP

mevalonate kinase (EC 2.7.1.36)

MEVP

5

MEVP + ATP → MEVPP + ADP

phosphomevalonate kinase (EC 2.7.4.2)

MEVPP

6

MEVPP + ATP → IPP + PO3 + CO2 + ADP

MEVPP decarboxylase

(EC 4.1.1.33)

IPP

7

IPP eftrightarrow DMAPP

IPP isomerase

(EC 5.3.3.2)

DMAPP

8

IPP + DMAPP → GPP

GPP synthase

(EC 2.5.1.1 atau EC 2.5.1.10)

GPP

9

IPP + GPP → FPP

FPP synthase

(EC 2.5.1.1 atau EC 2.5.1.10)

FPP

10

FPP → sesquiterpenoid

sesquiterpene synthase

sesquiterpenes

  1. a Order of occurrence in the MEV pathway
  2. b Main product that serves as the substrate for the next reaction in the MEV pathway