Skip to main content

Table 1 Reactions involved in the MEV pathway (in order of occurrence)

From: Simulation of a Petri net-based Model of the Terpenoid Biosynthesis Pathway

Ordera Reaction Enzyme Main productb
1 acetylcoA + acetylcoA → acetoacetyl-coA + coA acetylcoA C-acyltransferase
(EC 2.3.1.9)
acetoacetyl-coA
2 acetoacetylcoA + acetylcoA + H2O → HMGcoA + coA HMGcoA synthase (EC2.3.3.10) HMGcoA
3 HMGcoA + 2NADPH + 2H+ → mevalonate + coA + 2 NADP+ HMGcoA reductase (EC 1.1.1.34) MEV
4 MEV + ATP → MEVP + ADP mevalonate kinase (EC 2.7.1.36) MEVP
5 MEVP + ATP → MEVPP + ADP phosphomevalonate kinase (EC 2.7.4.2) MEVPP
6 MEVPP + ATP → IPP + PO3 + CO2 + ADP MEVPP decarboxylase
(EC 4.1.1.33)
IPP
7 IPP eftrightarrow DMAPP IPP isomerase
(EC 5.3.3.2)
DMAPP
8 IPP + DMAPP → GPP GPP synthase
(EC 2.5.1.1 atau EC 2.5.1.10)
GPP
9 IPP + GPP → FPP FPP synthase
(EC 2.5.1.1 atau EC 2.5.1.10)
FPP
10 FPP → sesquiterpenoid sesquiterpene synthase sesquiterpenes
  1. a Order of occurrence in the MEV pathway
  2. b Main product that serves as the substrate for the next reaction in the MEV pathway