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Figure 1 | BMC Bioinformatics

Figure 1

From: A hub-attachment based method to detect functional modules from confidence-scored protein interactions and expression profiles

Figure 1

A brief of HUNTER. (A) The flowchart of HUNTER. (B) An example of DNA Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination. An example of HUNTER predict cluster, a ten-protein cluster. The module seed of this cluster consists of one protein in yellow (YAR007C) and five proteins in pink (YJL173C, YCR028C-A, YML032C, YNL312W, and YHR164C) in the dashed circle. Among these six proteins, five proteins (YAR007C, YJL173C, YCR028C-A, YML032C, and YNL312W) form a fully connected subgraph (clique) in the PPI network. Proteins in green, YCR092C, YMR234W, YKL114C, and YER095W are the attachments to the module seed.

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BMC Bioinformatics

ISSN: 1471-2105

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