Figure 10
System dynamics for 60 mins: Comparison between simulation results using the complete and simple models and experimental plots generated by ThT fluorescence. Simulation vs experimental data for protofibril elongation from the Complete model. (A) results generated for kla= 2.1 h-1mM-1 and kla-= 6.0 x10-3 h-1. (B) kla= 9.0x10-1 h-1mM-1 and kla-= 6.0 x10-3 h-1. (C) simulation results from the Simple model for longer time-span. Isolated protofibrils were elongated using freshly purified Aβ monomers (green). Simulation plots modeling the elongation phase for longer time-scales (blue).