Figure 8

System dynamics for 1-5 mins: Comparison between simulation results using the simple model and experimental plots generated by ThT fluorescence. Simulation vs experimental data for protofibril elongation over 1 min (A), 2 min (B) and 5 min (C). Green curves are the elongation data for isolated protofibrils (2 µM, lower curve; 4 µM, middle curve; 7 µM, upper curve) elongated by freshly purified Aβ monomers (30 µM). Simulation plot modeling the elongation phase using simple model (blue).