Figure 5
From: Analysis and verification of the HMGB1 signaling pathway
Mutations of ARF, P21 and RAS affect the cell's fate. Mutations of the tumor suppressor proteins ARF and P21, and of the oncoprotein RAS affect the cell's fate, using ODE (A-C) and stochastic (D-F) simulations. The mutations of ARF (A, D) and P21 (B, E), and RAS (C, F), which correspond to small d ARF and dP 21, and large d RAS values, upregulate the expression level of the oncoproteins MDM2 and CyclinD/E, and downregulate p53's expression level.