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Table 2 Results from validation of the treated scenarios

From: Modeling the competition between lung metastases and the immune system using agents

Vaccination Injected Cells Median Range Estimated Prevention
"In vivo" experiment     
No - > 200 134 to > 200 -
Day 1 - 3 0 - 27 ≈ 99%
Day 7 - 26 1 - 165 ≥ 87%
"In silico" 100 mice Sample I     
No 35 30 23 - 34 -
Day 1 35 0 (mean 0.33) 0 - 2 ≈ 99%
Day 7 35 5 0 - 12 ≥ 83,3%
"In silico" 100 mice Sample II     
No 35 29 23 - 34 -
Day 1 35 0 (mean 0.21) 0 - 2 > 99%
Day 7 35 5 1 - 11 ≈ 82,7%
  1. Results obtained in the "in vivo" experiment and in the "in silico" experiments on mice Set I and II using the following vaccine protocols: "Untreated" (No vaccination), "Triplex+1" (Day 1) and "Triplex+7" (Day 7). The "Injected" column represents the number of cancer cells positioned in the lattice in the "In silico" experiments at the beginning of the simulation. The "Median" column shows the nodule medians obtained at the end of the experiments. The "Estimated prevention" column indicates the efficacy of a protocol in vaccinated mice in respect to untreated mice, and it is computed comparing the medians obtained in vaccinated mice against the medians obtained in untreated mice.