Modeling the competition between lung metastases and the immune system using agents

BMC Bioinformatics

Table 2 Results from validation of the treated scenarios

Vaccination	Injected Cells	Median	Range	Estimated Prevention
"In vivo" experiment
No	-	> 200	134 to > 200	-
Day 1	-	3	0 - 27	≈ 99%
Day 7	-	26	1 - 165	≥ 87%
"In silico" 100 mice Sample I
No	35	30	23 - 34	-
Day 1	35	0 (mean 0.33)	0 - 2	≈ 99%
Day 7	35	5	0 - 12	≥ 83,3%
"In silico" 100 mice Sample II
No	35	29	23 - 34	-
Day 1	35	0 (mean 0.21)	0 - 2	> 99%
Day 7	35	5	1 - 11	≈ 82,7%

Results obtained in the "in vivo" experiment and in the "in silico" experiments on mice Set I and II using the following vaccine protocols: "Untreated" (No vaccination), "Triplex+1" (Day 1) and "Triplex+7" (Day 7). The "Injected" column represents the number of cancer cells positioned in the lattice in the "In silico" experiments at the beginning of the simulation. The "Median" column shows the nodule medians obtained at the end of the experiments. The "Estimated prevention" column indicates the efficacy of a protocol in vaccinated mice in respect to untreated mice, and it is computed comparing the medians obtained in vaccinated mice against the medians obtained in untreated mice.

ISSN: 1471-2105