Figure 4
From: Mapping transcription mechanisms from multimodal genomic data
The distributed computing system to construct a TIM from a set of SNP and gene expression data. Each computer in the cluster is responsible for calculating a portion of the TIM. Once the mutual information of a SNP-gene pair is computed, it is immediately used to determine if the pair is independent, and the mutual information is only recorded for dependent pairs. Finally, consolidation of all computed mutual information values generates a complete TIM.