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Table 2 Reactions modeling translation

From: Stochastic sequence-level model of coupled transcription and translation in prokaryotes

Event

Reaction

Rate constant

Ref.

Initiation (14)

k trans_init = 0.33

[20]

Stepwise translocation (15-17)

k tm = 1000

[3]

Activation (18)

k transA = 35, k transB = 8,

k transC = 4.5

[20]

Back-translocation (19)

k bt = 1.5

[51]

Drop-off (20)

k drop = 0.000114

[45]

Trans-translation (21)

k tt = 0.000052

[46]

Elongation completion (22)

k trans_f = 2

[20]

Folding and activation (23)

k fold = 0.0024

[47]

Protein degradation (24)

k dec = 0.0017

[47]

  1. Chemical reactions and rate constants (in s-1) used to model translation initiation, elongation, and termination, as well as protein folding and activation, and protein degradation. Parameter values were obtained from measurements in E. coli, mainly for LacZ. References are reported in the column Ref.
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BMC Bioinformatics

ISSN: 1471-2105

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