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Table 2 Simulated FDR and Power Rate (10 Analyses)

From: Sequential interim analyses of survival data in DNA microarray experiments

  Analysis
  1 2 3 4 5
  mean sd mean sd mean sd mean sd mean sd
#found genes 0 0 10 85 164 437 1033 928 2404 915
FDR 0.003 0.055 0.029 0.119 0.048 0.145 0.034 0.061 0.028 0.006
APR 0.000 0.000 0.002 0.016 0.032 0.085 0.200 0.180 0.467 0.178
0.043 0.060 0.038 0.120 0.049 0.134 0.241 0.208 0.518 0.174
(S) 0.055 0.122 0.025 0.085 0.037 0.092 0.220 0.188 0.488 0.172
(L) 0.283 0.401 0.382 0.228 0.410 0.132 0.581 0.113 0.708 0.079
  6 7 8 9 10
  mean sd mean sd mean sd mean sd mean sd
#found genes 3414 637 3894 520 4092 471 4155 451 4167 446
FDR 0.027 0.004 0.027 0.004 0.027 0.004 0.027 0.004 0.027 0.004
APR 0.664 0.124 0.757 0.101 0.796 0.092 0.808 0.088 0.811 0.087
0.698 0.096 0.778 0.062 0.812 0.043 0.823 0.034 0.825 0.031
(S) 0.671 0.117 0.756 0.098 0.790 0.091 0.802 0.087 0.804 0.086
(L) 0.797 0.056 0.847 0.042 0.870 0.031 0.877 0.025 0.878 0.023
  1. The descriptive values for each interim analysis including the number detected genes, the simulated FDR, the real APR, and the APR estimates, all in the setting of τ = 50% altered genes with large fold changes and ten interim analyses. These values correspond to Figure 4 (b) and Figure 5 (b).