FunFOLD: an improved automated method for the prediction of ligand binding residues using 3D models of proteins

Roche, Daniel B; Tetchner, Stuart J; McGuffin, Liam J

doi:10.1186/1471-2105-12-160

BMC Bioinformatics

Table 3 The mean MCC and BDT raw scores and Z-scores obtained by FunFOLD are compared with those obtained by each CASP8 function prediction group - as in Table 1 except for CASP8 targets containing non-metal ligands or metal and non-metal ligands in the same binding site.

From: FunFOLD: an improved automated method for the prediction of ligand binding residues using 3D models of proteins

Group ID	N	Mean score for group		Mean score for FunFOLD		Increase in mean score		Mean Z-score for group		Mean Z-score for FunFOLD		P-value (raw score)		P-value (Z-score)		1 - p-value (raw score)		1 - p-value (Z-score)
		MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT	MCC	BDT
FN407	11	0.774	0.700	0.752	0.690	-0.022	-0.010	1.156	1.100	1.061	1.018	0.681	0.517	0.681	0.449	0.319	0.483	0.319	0.551
FN293	10	0.778	0.703	0.771	0.722	-0.006	0.020	1.101	0.008	1.074	1.077	0.423	0.278	0.423	0.313	0.577	0.722	0.577	0.688
FN163	11	0.723	0.705	0.752	0.690	0.029	-0.015	0.966	1.072	1.061	1.018	0.183	0.382	0.183	0.416	0.817	0.618	0.817	0.584
FN057	11	0.646	0.633	0.752	0.690	0.160	0.058	0.738	0.828	1.061	1.018	0.139	0.382	0.120	0.381	0.861	0.618	0.880	0.618
FN417	11	0.583	0.528	0.752	0.690	0.169	0.162	0.541	0.458	1.061	1.018	0.012	0.021	0.012	0.042	0.988	0.979	0.988	0.958
FN450	10	0.442	0.418	0.771	0.722	0.330	0.305	0.077	0.038	1.074	1.077	0.002	0.003	0.002	0.003	0.988	0.997	0.998	0.997
FN325	11	0.389	0.360	0.752	0.690	0.362	0.331	-0.076	-0.102	1.061	1.018	0.003	0.002	0.003	0.002	0.987	0.998	0.997	0.998
FN034	10	0.317	0.292	0.743	0.687	0.426	0.395	-0.026	-0.362	1.031	0.972	0.003	0.005	0.006	0.005	0.994	0.995	0.994	0.995
FN108	11	0.156	0.185	0.752	0.690	0.596	0.505	-0.819	-0.750	1.061	1.018	0.000	0.000	0.000	0.000	1.000	1.000	1.000	1.000
FN242	11	0.109	0.101	0.752	0.690	0.643	0.590	-0.965	-1.069	1.061	1.018	0.000	0.000	0.000	0.000	1.000	1.000	1.000	1.000
FN086	11	0.074	0.118	0.752	0.690	0.678	0.572	-1.061	-0.990	1.061	1.018	0.000	0.000	0.000	0.000	1.000	1.000	1.000	1.000
FN105	11	0.020	0.063	0.752	0.690	0.731	0.628	-1.260	-1.207	1.061	1.018	0.000	0.000	0.000	0.000	1.000	1.000	1.000	1.000

Back to article page

ISSN: 1471-2105

Contact us

General enquiries: journalsubmissions@springernature.com